Primary Motility  Disorders of the  Esophagus
 The Esophageal
 Esophagogastric  Junction

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Volume: The Esophagogastric Junction
Chapter: EGJ and GER disease

What is the prevalence of GERD in a population-based study?
G.R. Locke III (Rochester) 

Why is reflux esophagitis a predominantly male disease?
J. Sarosiek, R.W. McCallum (Kansas City) 

Why is the striking male predominance of GERD in adults not found in young children?
Y. Vandenplas (Brussels) 

Is the pathophysiology of regurgitant reflux in infants known?
S.R. Orenstein (Pittsburgh) 

Is there a correlation between scoring of GERD and the prevalence of symptoms?
R.M. Bremner, S.F. Hoeft, T.R. DeMeester (Los Angeles), M. Costantini (Padova) 

What factors may predict esophagitis in patients with GER?
J. Vatier, G. Cadiot, M. Mignon (Paris) 

Is the labeled food gastric emptying study reliable and of value in childhood GER?
C. Di Lorenzo (Pittsburgh) 

When is manometry indicated for reflux esophagitis? Do results of conventional manometry have therapeutic implications?
M. Gadenstätter (Innsbruck), C.G. Bremner (Los Angeles) 

Is the role of non acid GER in the pathogenesis of reflux esophagitis overestimated?
S. Mattioli, F. D'Ovidio, M. Pastina, M.P. Di Simone, L. Ferruzzi (Bologna) 

Can scanning electron microscopy be considered as a diagnostic test for GER disease?
B.T. Johnston, S. Nunn (Belfast) 

Can mucosal damage in GERD be graded endoscopically?
G.N.J. Tytgat (Amsterdam) 

Epithelial resistance

How can the lack of correlation between severity of clinical symptoms and mucosal injury be explained?
K. Geboes, N. Ectors (Leuven) 

Is there any correlation between alkaline reflux and the severity of esophagitis?
I. Braghetto, A. Csendes, P. Burdiles, O. Korn (Santiago) 

Is the gastric cardiac epithelium likely to be injured by reflux?
C.G. Bremner (Los Angeles) 

What is the relation between acid reflux, esophageal glycoconjugate (mucin) secretion, and viscosity?
J. Sarosiek, M. Marcinkiewicz, T. Zbroch, Z. Namiot (Kansas City) 

What is the correlation between the histological morphometric parameters and esophagitis in adults? In infants?
S.R. Orenstein (Pittsburgh) 

Is the effect of extracellular acidification on intracellular pH modified by pepsin?
N.A. Tobey (New Orleans) 

What are the mechanisms by which hydrogen ions damage the esophageal epithelium?
R.C. Orlando (New Orleans) 

What are the mechanisms involved in mucosal adaptative cytoprotection?
A.I. Lanas, J. Ortego (Zaragoza) 

What is known about the distribution and expression of growth factors, such as EGF and TGFa and their receptors, in the defense of the esophageal mucosa, and in healing of reflux induced injury?
A. Calabrò, B. Orsini, D. Renzi, L. Papi, S. Milani, C. Surrenti (Florence) 

What regulates bicarbonate secretion by esophageal submucosal glands?
N.A. Tobey (New Orleans) 

What is the role of salivary and esophageal PGE2 in esophageal protection?
J. Sarosiek, M. Marcinkiewicz, T. Zbroch, R.W. McCallum (Kansas City) 

Is salivary PGE2 output stimulated by esophageal inflammation?
J. Sarosiek, T. Zbroch, M. Marcinkiewicz, Z. Namiot (Kansas City) 

What is the relationship between free-radical release and extent of mucosal damage?
G.J. Wetscher, C. Profanter (Innsbruck), R.A. Hinder (Jacksonville) 

Respiratory disorders

Pharyngitis, laryngitis in the adult, and GER
C. Beauvillain de Montreuil (Nantes) 

Pseudo-asthma and GER
W.P. Mulloy (Philadelphia) 

What is the value of bronchial scintigraphy in conjunction with a meal?
D.S. Brandt, T.P. Chaudhuri, E.M. Smith (Hampton) 

       What are the potential mechanisms for esophageal acid-induced bronchoconstriction?
           S.J. Sontag (Hines) 

Of what value is the symptom association chance for this evaluation?
S.J. Sontag (Hines) 

Is the role of proximal acid reflux in respiratory symptoms prevalent in infants?
S.G. Jolley (Las Vegas), D.G. Johnson (Salt Lake City) 

What role does surgery have in treating these disorders?
M.G. Patti (San Francisco), A. Porter, C.A. Pellegrini (Seattle) 

What is the effect of documented acid suppression on asthma symptoms? On expiratory flow rates?
S.M. Harding (Birmingham) 

What are the predictors of response?
S.M. Harding (Birmingham) 

What is the effect of CPAP (continuous positive airway pressure) in limiting symptoms of nocturnal reflux?
J.P. Shoenut, P. Kerr, M.H. Kryger (Winnipeg) 

Is home CPAP a means of treatment for patients with nocturnal reflux resistant to treatment?
J.P. Shoenut, P. Kerr, M.H. Kryger (Winnipeg) 

Publication date: May 1998 OESO©2015