Primary Motility  Disorders of the  Esophagus
 The Esophageal
 Mucosa
 The
 Esophagogastric  Junction
 Barrett's
 Esophagus

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OESO©2015
 
Volume: The Esophagogastric Junction
Chapter: Esophageal columnar metaplasia (Barrett s esophagus)
 


What is the prevalence of Barrett's esophagus in patients with GER and in the general population?
A.J. Cameron (Rochester, MN) 

What is the incidence of development of Barrett's esophagus?
T. Schnell, S.J. Sontag (Hines) 

Is there an explanation for the predominance of Barrett's esophagus and adenocarcinoma in white male patients?
J. Sarosiek, R.W. McCallum (Kansas City) 

Is there any influence of diet on the development of Barrett's metaplasia?
G.W.B. Clark, D.J. Bowrey, M.K. Roy, P.D. Carey (Cardiff) 

What is the pathophysiology of reflux patients developing Barrett's esophagus?
A. Watson (London) 

Is it possible to precisely evaluate the impairment of esophageal sensitivity of Barrett's mucosa?
A. Watson (London) 

What is the role of bile reflux in the pathogenesis of Barrett's esophagus, as shown by experimental models?
S.E.A. Attwood (Salford) 

Is there a relationship between combined reflux of gastric and duodenal juice and metaplasia during mucosal healing?
M. Fein (Wursburg), C.G. Bremner (Los Angeles) 

What is the most frequent site of the stenosis?
J. Sarosiek, R.W. McCallum (Kansas City) 

What is the frequency of finding Helicobacter pylori in biopsies of patients with Barrett's esophagus? On which type of Barrett's metaplasia is it predominantly found? Could Helicobacter pylori be considered as a causative factor in Barrett's esophagus?
B.T. Cooper (Birmingham, UK) 

Could lowering of salivary and esophageal epidermal growth factor in severe esophagitis be related to the development of Barrett's mucosa?
J. Sarosiek, M. Marcinkiewicz, R.W. McCallum (Kansas City) 

What is the effect of epidermal growth factor on parietal cell function?
J. Del Valle (Ann Arbor) 

What precisions can be made on differences between Barrett's epithelium and intestinal metaplasia by immunocytochemistry? The role of a novel marker
L.H. Griffel, K.M. Das, I. Baron-Gabriel, P.S. Amenta (New Brunswick) 

What conclusions can be drawn from the enhanced expression of growth factors, cell adhesive molecules and oncogenes in the process of metaplasia?
G. Triadafilopoulos (Palo Alto) 

Endoscopy

How frequently is the diagnosis of Barrett's mucosa missed at the time of endoscopic examination?
E. Achkar (Cleveland) 

What dye-spraying technique should be chosen in cylindric mucosa?
H.J. Dittler, W.K.H. Kauer (Munich) 

What is the endoscopic prevalence of short segments of Barrett's esophagus?
A.J. Cameron (Rochester, MN) 

What is the most accurate method of diagnosing specialized columnar epithelium in Barrett's mucosa?
M.I.F. Canto (Baltimore) 

Is it ever possible to make unequivocal histological diagnosis of Barrett's mucosa without goblet cells?
R.H. Riddell (Hamilton) 

What can be expected from magnification endoscopy?
C.J. Lightdale (New York) 

What can be expected from computerized image-processing techniques in the quantification and mapping of Barrett's mucosa?
R. Kim, J.C. Reynolds (Pittsburgh) 

What is the value of brush cytology in the diagnosis of non-dysplastic Barrett's esophagus?
H.D. Appelman (Ann Arbor) 

What can be expected from the new 12 and 20 MHz miniprobes in visualizing these additional echo-layers?
R. Lambert (Lyons) 

Treatments

Are PPIs alone able to induce regression of the length of Barrett's esophagus?
R.E. Sampliner (Tucson) 

Is there a clinical significance to the development of squamous islands in Barrett's mucosa under treatment?
R.E. Sampliner (Tucson) 

Is ablation of the esophageal columnar tissue more likely to induce restoration of squamous epithelium than just acid suppression?
M.M. Berenson (Salt Lake City) 

What are the results of photodynamic therapy for Barrett's esophagus?
B.F. Overholt, M. Panjehpour (Knoxville) 

What are the compared results of photothermal laser therapy and photodynamic therapy for the eradication of Barrett's esophagus?
H. Barr (Gloucester) 

Does phototherapy induce regression of Barrett's columnar-lined esophagus?
R. Lambert (Lyons) 
A. Watson (London) 

What is the evidence to support the presence of a multipotential precursor cell in the glandular epithelium?
M.M. Berenson (Salt Lake City) 

What are the indications for AR surgery in Barrett's esophagus?
H.J. Stein, J.R. Siewert (Munich) 

Is there any beneficial effect to be expected from highly selective vagotomy in addition to AR surgery?
A.N. Kingsnorth (Liverpool) 

Should intra-operative manometry be routinely done in Barrett's patients?
I. Cecconello, A. Nasi, H.W. Pinotti, M.A. Oliveira (Sao Paulo) 

Evolution

What is the evolution of Barrett's mucosa after AR surgery
H. Hölscher, C. Gutschow, K.T.E. Beckurts, P. Schneider (Cologne) 

How should endoscopic surveillance of Barrett's esophagus in adults be conducted?
C.G. Bremner (Los Angeles) 

How should endoscopic surveillance of Barrett's esophagus in children be conducted?
E. Hassall (Vancouver) 

What is the value of methylene blue stained biopsies in endoscopic surveillance of patients with Barrett's esophagus?
M.I.F. Canto (Baltimore) 

Is India ink a more effective method for the follow-up of Barrett's mucosa?
R.T. Shaffer (Houston) 

What is the role of radiology in evaluating patients with Barrett's esophagus?
M.Y.M. Chen, D.J. Ott (Winston-Salem) 

What is the value of radionuclide scanning in the surveillance of patients with Barrett's esophagus?
E.M. Smith, K.H. Gladden, S. Fink, T.K. Chaudhuri (Hampton) 

What are the most useful non-histological markers of malignant potential?
A.N. Kingsnorth (Liverpool) 

Is there a relationship between the length of Barrett's esophagus and the presence or degree of dysplasia?
S.R. Hamilton (Baltimore) 

Is it possible to make the unequivocal diagnosis of "dysplasia", especially "low-grade dysplasia" in Barrett's mucosa?
K. Geboes (Leuven) 

Of what value is the determination of DNA ploidy in the classification of epithelial changes in Barrett's mucosa?
A.H. Mulder, M.B.E. Menke-Pluymers, H.W. Tilanus, M. van Blankenstein, W.C.J. Hop (Dordrecht) 

Is the natural history of high-grade dysplasia known?
K. Geboes, P. De Paepe (Leuven) 

What is the risk of nodal metastasis from superficial adenocarcinoma arising in Barrett's esophagus?
R.C. Haggitt (Seattle) 

Should quality of life influence the decision of esophagectomy in high grade dysplasia?
D. Provenzale (Durham) 

Does "regression" of Barrett's mucosa lessen the risk of developing dysplasia and cancer in Barrett's mucosa?
F.H. Ellis (Boston) 

Early detection of malignancy

What is known about growth factors, oncogenes, and tumor suppressor genes in the evolution of Barrett's dysplasia and carcinoma?
J.J.B. van Lanschot, W. Polkowski, H. Obertop, G.J.A. Offerhaus (Amsterdam) 

Do studies of PCNA and Ki67 immunolocalization in Barrett's mucosa offer any information about the neoplastic progression?
A.N. Kingsnorth (Liverpool) 

Of what value are the genetic changes : are the loss of the Y-chromosome and deletions or mutations of the adenomatous polyposis coli (APC) gene on chomosome 5q21 important in the evolution of Barrett's dysplasia and carcinoma?
H.W. Tilanus, M.B.E. Menke-Pluymers (Rotterdam) 

What does the simultaneous expression of Lewis antigen and sulphomucins tell about patients at risk for dysplasia and carcinoma?
J. Torrado, J. Garay (San Sebastian) 

What can be expected from laser induced fluorescence?
K.K. Wang, M.W.K. Song, A. Norbasch, F. Prendergast (Rochester, MN) 

What is the current status on the quality-adjusted ratio and cost-effectiveness of screening for Barrett's cancer in males and females?
A.N. Kingsnorth (Liverpool) 

Is there a use for EUS in the follow-up of patients to detect early recurrences after treatment?
R. Lambert (Lyons) 

What is the value of proton magnetic resonance in detecting early malignant changes?
G.L. Falk, P. Barry, C. Wadström, P. Shehan, P. Russell, C.L. Lean, C.E. Mountford (Sydney) 

What is the relationship between p53 gene aberrations and other genetic events in the progression from benign Barrett's mucosa to carcinoma?
J.F. Fléjou (Paris) 


Publication date: May 1998 OESO©2015