Primary Motility  Disorders of the  Esophagus
 The Esophageal
 Esophagogastric  Junction

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Volume: Barrett's Esophagus
Chapter: Pathophysiology

Acid reflux

What is known about the pattern of acid exposure on differentiation in Barrett's esophagus? What is the significance of microvilli formations? What is the relationship between cell differentiation and proliferation?
R.C. Fitzgerald, R. Lascar, G. Triadafilopoulos  

Is gastric secretion different in Barrett patients and in patients with reflux esophagitis?
M. Fein, K.H. Fuchs, S.M. Freys  
B.I. Hirschowitz  

What information can cell or organ culture bring on the mechanism of the proliferation response of Barrett's esophagus to acid?
G. Triadafilopoulos, R.C. Fitzgerald  

Is acid exposure at all esophageal levels higher in Barrett's esophagus than in common reflux disease?
A.P.M. Smout, E.C. Niemantsverdriet, R. Breumelhof, R. Timmer  

How should low prevalence of Barrett's esophagus in patients with Zollinger-Ellison syndrome be interpreted?
E. Sekera, R.T. Jensen, M. Mignon  

In Barrett's patients, what can be concluded from the continuous measurement of gastric pH over a circadian cycle?
V. Savarino, L. Tessieri, P. Dulbecco  

Does endoscopic evaluation of the flap valve predict reflux status?
L.D. Hill, R.A. Kozarek, C.E. Pope  

Based on experimental findings of the protective effect of acid secretion against adenocarcinoma, how should the role of continuous acid suppression on the development of esophageal metaplasia and adenocarcinoma in patients with duodenogastric reflux be considered?
M. Fein, K.H. Fuchs  

Are there specific abnormalities in esophageal function existing in Barrett's patients?
H.J. Stein, W.K.H. Kauer, J.R. Siewert  

What are the indications for esophageal pH monitoring in children with Barrett's disease?
S.R. Orenstein  
M. Banemai, G. Tougas  

Alkaline reflux

What is the relationship between bile and alkaline reflux?
J.E. Richter  

What is the relationship between esophageal exposure to bilirubin and esophageal pH or symptoms?
C.G. Streets, C.G. Bremner  

What is the prevalence of alkaline material in Barrett patients?
W.K.H. Kauer, H.J. Stein, J.R. Siewert  

Can quantitative data on alkaline refluxate be expected from any measurement system?
P. Burdiles  

Is there a correlation between the detrimental effects of bile reflux and the value of the pH in the refluxate?
W.K.H. Kauer, H.J. Stein, J.R. Siewert  

Can temporal evaluation of reflux events in Barrett's esophagus patients allow for understanding of mucosal damage?
A. Anggiansah, R.E.K. Marshall, W.J. Owen  

Can liquid diet, avoiding food interference, be advised in duodenogastric reflux detection by Bilitec™?
K.-H. Fuchs, M. Fein, J. Maroske, S.M. Freys  

In patients with esophagitis, does gastric surgery increase the prevalence of Barrett's esophagus?
P. Parrilla, L.F. Martínez de Haro, A. Ortiz, R. Lirón, V. Munitiz  

In patients with Barrett's esophagus, what is the prevalence of Helicobacter pylori infection in the antrum? In the cardia?
D.J. Bowrey, G.W.B. Clark  

What is the role of Helicobacter pylori in intestinal metaplasia above, below, and at the gastroesophageal junction?
R.M. Genta  

Helicobacter pylori and intestinal metaplasia at the esophagogastric junction: the US experience
R.K.H. Wong  

Helicobacter pylori and intestinal metaplasia at the esophagogastric junction. European experience
M. Voutilainen, T. Rantanen, P. Sipponen  

Should the non-eradication of Helicobacter pylori and gastritis allow for the reduction of parietal cell mass to the point that reflux associated symptoms are no longer a problem?
R.H. Riddell  

Achalasia and Barrett's esophagus

Can the rate of Barrett's metaplasia in treated achalasia be evaluated?
R.D. Szyjkowski  

Is preexisting gastroesophageal reflux necessary for the development of Barrett's esophagus in patients with achalasia?
F.H. Ellis  

What can be concluded from 24-hour pH studies in patients with achalasia?
J.M. Streitz, F.H. Ellis  

Are there any molecular markers, including genetic, that occur in Barrett's mucosa prior to histologic dysplasia?
J.D. Mueller  

What are the advantages of a new simplified classification system of dysplasia?
R.H Riddell  

Publication date: August 2003 OESO©2015