Monday, April 7, 8:20 - 9:50 a.m. - Room Van Dongen

Benefits of extended acid suppression Novel pharmacologic targets in GERD

C. Scarpignato (Italy)  -  G. Tougas (Switzerland)

Potential benefits of extended acid suppression with long-acting PPIs C. Scarpignato (Parma)
Compared effect of PPIs on Nocturnal Acid Breakthrough (NAB) R.H. Hunt  (Hamilton)
Impaired GI motility: still a valuable target for GERD therapy R. Penagini  (Milan)
Combined  antisecretory and prokinetic therapy: is it worthwile? G. Tougas (Basel)
Benefit and risks of prokinetic therapy M. Fried (Zurich)
Prokinetics of the future: novel pharmacological targets  M. D’Amato (Monza)

     

Monday, April 7, 8:20 - 9:50 a.m. - Room Poulenc

Interdisciplinary approaches to understanding GERD: The interface between Physiology and Mechanics

J.G. Brasseur (USA)  - H. Gregersen (Denmark) – L.S. Miller (USA)
The interface between anatomy and physiology: the 3-component sphincter L.S. Miller (Philadelphia)

The interface between mechanics and physiology: function and dysfunction J.G. Brasseur (University Park)

Mechanical vs physiologic characteristics of sphincteric muscle: tone, compliance, and opening H. Gregersen

Mechanosensation and other pathways from the mechano-receptor to the CNS A. Drewes (Aalborg)

The process of reflux as measured with high-resolution manometry, impedance and imaging J. Pandolfino  (Chicago)

Mechano-physiology of longitudinal muscle with reflux: normal vs GERD R.K. Mittal (San Diego)

     
Monday, April 7, 11:00 a.m. - 12:30 p.m. - Room Van Dongen

Pathologists' views on Barrett's mucosa, dysplasia and carcinoma

G. Chejfec (USA)  -  K. Takubo (Japan)
Discussant: E. Wiley (USA)
Is there any way (or are there any attempts) to improve the inter-observer variability in the diagnosis of low-grade dysplasia in Barrett’s mucosa? K. Geboes (Leuven)
Is differentiation between mucosal and submucosal invasion always possible in EMR specimens? E. Wiley(Chicago)

What are the precursors of adenocarcinoma arising after endoscopic mucosal ablation? J.Hart  (Chicago)

What is the clinical relevance of histologic subtyping of esophageal adenocarcinomas? R.H. Riddell (Toronto)
Should intestinal metaplasia be required for the diagnosis of precancerous columnar epithelium in the lower esophagus? The perspective of the pathologist? R.D. Odze  (Boston)

What is the prognostic significance of adenocarcinoma  invading into the connective tissue layer between the duplicated muscularis mucosae in Barrett’s mucosa? H. Van Dekken  (Rotterdam)
What are the histologic features in biopsies from Barrett’s mucosa containing high-grade dysplasia that indicate that there is invasive carcinoma in the lamina propria as well? H.D. Appelman (Ann Arbor)
In EMR specimens of Barrett’s esophagus, what type of mucosa is most common nest to areas of high-grade dysplasia? Next to superficial adenocarcinomas? K. Takubo (Tokyo)

     


Tuesday, April 8, 8:00 - 9:50 a.m. - Room Van Dongen

The origin of adenocarcinoma at the EG junction

R. Lambert (France) - C.J. Lightdale (USA) - R.H. Riddell (USA)

Definition of the EG junction and EG region G. De Hertogh (Leuven)
The ultra-short Barrett C.J. Lightdale (New York)   K. Takubo  (Tokyo)   K. Geboes (Leuven) 
- What are the means of diagnosis of US Barrett with Z line almost in place?
- Palisade vessels and squamous islands under the Z line and distinction from cardiac mucosa
- The value of sub-mucosal gland ducts as a marker for the anatomic esophagus in Barrett tissue
- The significance of ectopic islands of esophageal cardiac mucosa
- The role of intestinal metaplasia
- Definition of columnar metaplasia in the esophagus and of BE without intestinal metaplasia
Carditis H.D. Appelman  (Ann Arbor) H. El Zimaity (Hamilton)
- What is the prevalence of intestinal metaplasia in carditis?
- What is the role of intestinal metaplasia in carcinogenesis at this site?
Molecular biology J. Behar (Providence) P. Hainaut (Lyons)  B. Brücher (Tübingen)
- Are there distinct molecular characters in intestinal metaplasia and in carditis?
- What are the distinct types of p53 mutations in esophageal and cardia carcinoma?
- What is the distinct ratio CK7 / CK 20?
Endoscopic exploration of the esophagus K.K. Wang (Rochester)
 
-
 What can be expected from light-induced fluorescence endoscopy and NBI in detection of intra-epithelial neoplasia?

     


Tuesday, April 8, 11:00 a.m. - 12:30 p.m. - Room Van Dongen

Esophageal motility disorders

R. Penagini (Italy)  -  C. Prakash Gyawali (USA)

Does high resolution manometry better define ineffective motility, spastic disorders, and abnormal bolus flow? C. Prakash Gyawali (St Louis)

Should diaphragmatic crural contraction be included in description of esophageal motility? J.E. Pandolfino (Chicago)

What is the role of esophagography (barium studies) in motility disorders? J.E. Richter (Philadelphia)

Is multiple rapid swallowings during esophageal manometry helpful in clinical practice? D. Sifrim (Leuven)

Is there a benefit to impedance testing in patients with non obstructive dysphagia? E.H. Metman (Tours)

Can aerophagia and rumination be distinguished from other motility disorders by esophageal function testing? R. Tutuian (Zurich)

     


Wednesday, April 9, 8:20 - 9:50 a.m. - Room Van Dongen

Innovations in assessing gastric emptying and the new pharmacology in the foregut

R.W. McCallum (USA)  -  H.P. Parkman (USA)
Disorders of gastric emptying D. Sifrim (Leuven)
Gastric emptying scintigraphy. Consensus recommendations H.P. Parkman (Philadelphia)
New techniques for assessment of gastric emptying: SmartPill, Breath testing, and MRI R.W. McCallum (Kansas City)
Evolving pharmacology for treating gastric emptying disorders J. Tack (Leuven)

     

Wednesday, April 9, 8:20 - 9:50 a.m. - Room Poulenc

Standard and/or flexibility in the upper GI endoscopy
Ways to diagnostical and interventional endoscopy

I.F. Herrmann (Italy) -  H.W. Boyce (USA)
Transnasal endoscopy without local anesthesia   I.F.Herrmann (Rome)
The sitting position, the recumbent position and the movement I.F. Herrmann (Rome)
Overcoming space limitations - endosonography using miniprobes D.Domagk (Münster)

Cost / benefit for different systems H.P.Werner (Bischofshofen)
Improvements
  - in endoscopy using the transnasal way M.Strahl (Düsseldorf)
  - in design of disposable canal-systems B.Matteja (Turin)
  - in avoiding contamination-risks P.Heeg (Tübingen)

     

Wednesday, April 9, 11:00 a.m. - 12:30 p.m. - Room Van Dongen

New endoscopic surveillance modalities for Barrett’s esophagus

A.G. Casson (Canada) – P. D. Siersema (Netherlands)
The new approach to Barrett’s esophagus from the computational biologist’s perspective C.C. Maley (Philadelphia)
Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett's esophagus surveillance population. K.K. Wang (Rochester)
Ex-vivo study of high-magnification chromoendoscopy in the gastrointestinal tract to determine the optimal staining conditions for endocytoscopy. A. Hoffman (Mainz)

Optical detection of esophageal dysplasia  H.C. Wolfsen (Jacksonville)

Is there a relationship between the length of Barrett's esophagus and normalization of intestinal metaplasia? J.D. Horwhat (Bethesda)

Potential application of infrared spectromicroscopy and synchrotron light to characterize Barrett's esophagus A.G. Casson(Saskatoon)