Lee L. Swanström (USA-France)

Jie He (China)

Michio Hongo (Japan)


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Session 1


Sunday, September 3
8:00 – 10:00 am

Room 1



Neuro-physiology of the esophagus


Chairs: Sutep Gonlachanvit (Thailand) – Hans Gregersen (Denmark-China)

Discussant: Larry Miller (USA)


The Esophagus-brain-esophagus axis

  • Brain imaging methods and esophagus-brain axis
  • How can brain source modeling advance our understanding of the esophagus-brain axis?
  • How can evoked brain potentials advance our understanding of the esophagus-brain axis?
  • What are the characteristics of esophageal afferents in humans?
  • Can efficacy of the esophagus be improved by neurophysiological means?
  • What are the compensatory neurophysiological mechanisms for impaired esophageal mucosal defense?

Multimodal stimulation and sensitization

  • How do we best study mechano-sensitive afferents in humans and in animal experiments?
  • What does distension studies reveal about esophageal efficacy and neurophysiological mechanisms?
  • What are the effects of physical and chemical stimulation of the esophageal body on UES opening and relaxation in normal subjects, elderly or in relation to esophageal disease?
  • Do compensatory neurophysiological mechanisms exist for impaired esophageal transport?
  • What are the differences in neurophysiological characteristics of the proximal and distal esophagus?

The aging esophagus and diseases

  • Why is esophagus function impaired in elderly and which symptoms does the impairment cause?
  • What is the clinical impact of sensitization of esophageal afferents?
  • What is the role of TRPV1 in reflux hypersensitivity?
  • How are swallowing and respiration coordinated in elderly and in pulmonary diseases?




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