Lee L. Swanström (USA-France)
Jie He (China)
Michio Hongo (Japan)
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Sunday, September 3
8:00 – 10:00 am
Neuro-physiology of the esophagus
Chairs: Sutep Gonlachanvit (Thailand) – Hans Gregersen (Denmark-China)
Discussant: Larry Miller (USA)
The Esophagus-brain-esophagus axis
- Brain imaging methods and esophagus-brain axis
- How can brain source modeling advance our understanding of the esophagus-brain axis?
- How can evoked brain potentials advance our understanding of the esophagus-brain axis?
- What are the characteristics of esophageal afferents in humans?
- Can efficacy of the esophagus be improved by neurophysiological means?
- What are the compensatory neurophysiological mechanisms for impaired esophageal mucosal defense?
Multimodal stimulation and sensitization
- How do we best study mechano-sensitive afferents in humans and in animal experiments?
- What does distension studies reveal about esophageal efficacy and neurophysiological mechanisms?
- What are the effects of physical and chemical stimulation of the esophageal body on UES opening and relaxation in normal subjects, elderly or in relation to esophageal disease?
- Do compensatory neurophysiological mechanisms exist for impaired esophageal transport?
- What are the differences in neurophysiological characteristics of the proximal and distal esophagus?
The aging esophagus and diseases
- Why is esophagus function impaired in elderly and which symptoms does the impairment cause?
- What is the clinical impact of sensitization of esophageal afferents?
- What is the role of TRPV1 in reflux hypersensitivity?
- How are swallowing and respiration coordinated in elderly and in pulmonary diseases?