Lee L. Swanström (USA-France)
Jie He (China)
Michio Hongo (Japan)
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Sunday, September 3
2:00 – 4:00 pm
Hot topics in esophageal pathology
Chairs: ILKe Nalbantoglu ( USA) – Maria Westerhoff (USA)
Discussants: Henry D. Appelman (USA) – Laura Rubbia-Brandt (Switzerland)
Eosinophilic esophagitis (EoE)
- What is the rationale for the choice of 15 eosinophils per HPF as the cutoff for diagnosis?
Heather Dawson (Switzerland)
- How many biopsies are needed to exclude the diagnosis of EoE with confidence, and how big should they be? Dhanpat Jain (USA)
- What do degranulated eosinophils in the squamous epithelium mean in terms of diagnosis of EoE?
Paul E. Swanson (Canada)
- Is there any evidence that biopsies of endoscopically normal mucosa are cost effective in the diagnosis of EoE? Xuchen Zhang (USA)
- Is EoE with normal esophagus endoscopically the same as EoE with typical endoscopic findings?
Rebecca Wilcox (Canada)
- Is it important to diagnose fibrosis of the lamina propria in EoE biopsies? Hala El-Zamaity (Canada)
- In the absence of an esophageal motility disorder, does the histologic diagnosis of lymphocytic esophagitis have any clinical meaning? Rhonda K. Yantiss (USA)
- In order to diagnose lymphocytic esophagitis, is it necessary that careful counts of intra-epithelial lymphocytes be performed? Suntrea T. Hammer (USA)
- Is lymphocytic esophagitis with the endoscopic appearance of EoE a specific disease?
Deepa T. Patil (USA)
- What is the natural history of lymphocytic esophagitis? Rupert Langer (Switzerland)
Is reflux esophagitis ever a histologic diagnosis? A debate
Yes -------------- No
Cathy S. Streutker (Canada) Monika Tripathi (UK)
- What drugs commonly induce endoscopic and histologic changes in the esophagus?
Purva Gopal (USA)
- Is there an acute esophageal bacterial infection, and what does it look like in biopsies?
Mikhail Livosky (USA)
- What are the histologic esophageal manifestations of dermatologic diseases? Joanna Gibson (USA)
- What are the causes of sloughing esophagitis (esophagitis dessicans superficialis)?
Ilke Nalbantoglu (USA)
- There is a 1.5 cm length of endoscopic columnar mucosa in the distal esophagus. Eight (8) biopsies contain columnar mucosa that does not have a single goblet cell. In the UK, this is Barrett’s mucosa, but what is it in the US? Robert H. Riddell (Canada)
- Pancreatic acinar cells are common in biopsies of the cardia. We refer to them as a metaplasia. What is the proof that they are metaplastic rather than simply being a normal variant? Maria Westerhoff (USA)
- Why, following injury such as reflux, is it necessary for metaplastic columnar mucosa to develop, and what is the purpose of the goblet cells? Andrew M. Bellizzi (USA)
- Should all irregular Z-lines be biopsied in order to detect intestinal metaplasia?
Sara Hafezi Bakhtiari (Canada)
- What is the significance of intestinal metaplasia in the esophagus that is less than 1 cm long?
E. Celia Marginean (Canada)
Unique case discussions
- Pseudo-angiomatous SCC. Rebecca Wilcox (Canada)
- Carcinoma cuniculatum: how can one make a confident diagnosis on biopsy?
Geneviève Soucy (Canada)