Plenary Session 1











Attenzione: apre in una nuova finestra.

1 Sunday, September 2, 8:00 – 9:45 am
Physiology UES – Body – LES

Chairs:
L.S. Miller (Philadelphia) – K.R. DeVault (Jacksonville)
Discussant:
B.P. McMahon (Dublin)
Secretary: A. Vegesna (Philadelphia)

  • Is there a neurophysiological relationship between the proximal and distal esophagus? D. Sifrim (London)
  • What are the differences in esophageal muscle "in vitro" properties between the lower esophageal circular muscle, the clasp muscle, and the sling fibers? M.R. Ruggieri (Philadelphia)
  • What new modalities (in vivo & in vitro) can be used to evaluate the HPZ of the proximal and distal esophagus (FLIP, MicroCT, EUS)? A. Vegesna (Philadelphia)
  • What is the effect of laryngeal stimulation on the UESP? Is this effect reproducible? R.K. Mittal (San Diego)
  • To what extent can fluoroscopy and manometry with biomechanics define the various stages of UES opening? B.P. McMahon (Dublin)
  • Is there a mechanical relationship between anterior hyoid movement, extent of UES opening and aspiration? A. Ouyang (Hershey)
  • What is the relationship between pharyngeal contraction, relaxation of upper esophageal sphincter muscle and function in the normal swallow and with dysphagia? A. Ouyang (Hershey)
  • What is the function of the muscularis mucosa in the esophagus? L.S. Miller (Philadelphia)
  • What are the differences in esophageal muscle between the striated, transition zone, proximal smooth muscle, distal smooth muscle and LES muscle? How do they affect the "in vivo" compliance and contractility of the esophagus? J.G. Brasseur (University Park)
  • What is the current understanding of the coordination of contraction passage from proximal to transition to smooth muscle esophageal segments? J.G. Brasseur (University Park)
  • Which are the most important excitatory and inhibitory neurotransmitters regulating the esophageal striated and smooth muscle esophagus? P. Clavé (Mataro)
  • What non-pharmacological approaches are available that can alter the gastro-esophageal sphincter function? A. Ouyang (Hershey)
  • What is the evidence for a physiological sphincter without an anatomical counterpart within the gastro-esophageal segment? L.S. Miller (Philadelphia)
  • Understanding the sphincteric components of the gastro-esophageal segment that are responsible for the generation of the high-pressure zone at the esophago-gastric junction. R.K. Mittal (San Diego)
  • Do longitudinal muscles of the esophagus contract during various types of LES relaxation and what is its role in LES function? R.K. Mittal (San Diego)
  • What physiologic abnormalities are present in the muscles of the HPZ in GERD subjects vs normal control subjects (in vitro & in vivo). M.R. Ruggieri (Philadelphia)