Plenary Session 8











Attenzione: apre in una nuova finestra.

8 Monday, September 3, 4:30 – 6:15 pm
Barrett's esophagus and cancer

Chairs:
L. Bonavina (Milan ) –  W.A. Phillips (Melbourne)
Discussant: R.C. Fitzgerald (Cambridge)
Secretary: S. Siboni (Milan)

  • Which molecular changes (amplification/deletion/mutation) are associated with progression from Barrett’s to adenocarcinoma? R.C. Fitzgerald (Cambridge)
  • What is the status of predictive biomarkers based on identified molecular genetic changes? R.C. Fitzgerald (Cambridge)
  • Which molecular changes (amplification/deletion/mutation) are associated with EAC? D.G. Beer (Ann Arbor)
  • Which molecular alterations in EAC represent potential targets for therapy? D.G. Beer (Ann Arbor)
  • What is the role of implication of the genes encoding interleukin (IL-1b) and Tumor Necrosis Factor (TNFa)? K. Dvorak (Tucson)
  • Does the Shh/Bmp4/Sox9 pathway have a role in the development of Barrett's oesophagus? W.A. Phillips (Melbourne)
  • Bile acids and nuclear receptors in esophageal carcinogenesis. M.K. Gibson (Pittsburgh)
  • What is the “intrinsic” inflammatory pathway and how does it contribute to carcinogenesis in Barrett’s esophagus? K. Dvorak (Tucson)
  • What is the role of Cox-1 and Cox-2 in progression of non-dysplastic BE to adenocarcinoma? J. Sarosiek (El Paso)
  • Is limited surgical resection an adequate procedure for submucosal adenocarcinoma of the esophagogastric junction? P.M. Schneider (Zurich)
  • Can sentinel node technology secure limited surgical resections for adenocarcinoma of the esophagogastric junction? S. Perretta (Strasbourg)                      
  • What is the current evidence for various types of resection for adenocarcinoma of the  esophago-gastric junction based on Siewert’s classification? C. Schuhmacher (Munich)
  • Is extended mediastinal lymphadenectomy (2-field-LAD) the gold standard for surgical resection of esophageal adenocarcinoma? S. Law (Hong Kong)
  • What is the influence of prior EMR on complications and outcomes following RFA in BE? R.I. Rothstein (Lebanon)